Parkinson’s Disease is a disorder of the central nervous system that is characterized by impaired motor abilities including tremor, slowed and rigid mobility, unintentional movements, and even cognitive dysfunction (e.g., fluctuations in alertness, mild memory impairment). Regular physical activity is beneficial in slowing the progression of PD. In PD, neurodegeneration of the dopaminergic neurons in the substantia nigra occurs, damaging motor and reward systems.  Researchers compared PD patients who exercised to those who did not, and found that regular exercise slowed patient’s physical and cognitive decline but intermittent activity did not. Furthermore, exercise needed to be task and context specific to target declining functions in PD. For example, activities involved with balance-control, like Tai-Chi, better maintained postural and gait function compared to other activities. PD patients involved in household and work-related activities showed slower decline in activities of daily living (ADLs) and cognition. Additionally, regular physical activity increased corticostriatal plasticity and increased dopamine (DA) release stimulating increased activation of the striatum, possibly contributing to improved PD symptoms in those that habitually exercise. An encouraging takeaway from these findings suggests that something as simple as regularly sustained physical activity may lead to a modification in the typical trajectory of PD, slowing the rate of both the physical and cognitive decline, something that PD medications currently cannot accomplish. Furthermore, low levels of the brain protein clusterin predicts faster cognitive decline and dementia progression; clusterin increases with sustained exercise and may contribute to neurologic benefit.